[HTML][HTML] Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2
T Aikawa, GV Segre, K Lee - Journal of Biological Chemistry, 2001 - ASBMB
Fibroblast growth factor (FGF) and its receptor (FGFR) are thought to be negative regulators
of chondrocytic growth, as exemplified by achondroplasia and related chondrodysplasias,
which are caused by constitutively active mutations in FGFR3. To understand the growth-
inhibitory mechanisms of FGF, we analyzed the effects of FGF2 on cell cycle-regulating
molecules in chondrocytes. FGF2 dramatically inhibited proliferation of rat chondrosarcoma
(RCS) cells and arrested their cell cycle at the G 1 phase. FGF2 increased p21 expression in …
of chondrocytic growth, as exemplified by achondroplasia and related chondrodysplasias,
which are caused by constitutively active mutations in FGFR3. To understand the growth-
inhibitory mechanisms of FGF, we analyzed the effects of FGF2 on cell cycle-regulating
molecules in chondrocytes. FGF2 dramatically inhibited proliferation of rat chondrosarcoma
(RCS) cells and arrested their cell cycle at the G 1 phase. FGF2 increased p21 expression in …
