Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome

MF Jimenez, RWG Watson, J Parodo, D Evans… - Archives of …, 1997 - jamanetwork.com
Objective: To study the effect of the systemic inflammatory response syndrome (SIRS) or
major elective surgery on the apoptosis of circulating polymorphonuclear neutrophils
because an activated inflammatory response is terminated, in part, through the programmed
cell death, or apoptosis, of its effector cells. Design: A prospective inception cohort study.
Setting: A mixed surgical and medical intensive care unit of an adult tertiary care hospital.
Patients: Sixteen patients with SIRS, 7 uninfected patients who had undergone elective …