Intestinal permeability is increased in a proportion of spouses of patients with Crohn's disease
NP Breslin, C Nash, RJ Hilsden, NB Hershfield… - The American journal of …, 2001 - Elsevier
OBJECTIVE: Increased small intestinal permeability has been found in patients with Crohn's
disease and in a proportion of their healthy relatives. This may reflect a shared environment
or shared genes. The finding of abnormal permeability in the healthy spouses of patients
would favor an environmental cause for this observation. METHODS: The healthy spouses
of patients with Crohn's disease attending three gastroenterology clinics were invited to
participate. Eligible subjects consumed a 350-ml solution containing lactulose, mannitol …
disease and in a proportion of their healthy relatives. This may reflect a shared environment
or shared genes. The finding of abnormal permeability in the healthy spouses of patients
would favor an environmental cause for this observation. METHODS: The healthy spouses
of patients with Crohn's disease attending three gastroenterology clinics were invited to
participate. Eligible subjects consumed a 350-ml solution containing lactulose, mannitol …
