Ornithine decarboxylase antizyme: a novel type of regulatory protein
S Hayashi, Y Murakami, S Matsufuji - Trends in biochemical sciences, 1996 - cell.com
S Hayashi, Y Murakami, S Matsufuji
Trends in biochemical sciences, 1996•cell.comAntizyme plays an important regulatory role in the synthesis of ornithine decarboxylase
(ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating
polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting,
and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the
26S proteasome.
(ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating
polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting,
and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the
26S proteasome.
Antizyme plays an important regulatory role in the synthesis of ornithine decarboxylase (ODC), a key enzyme of polyamine synthesis in higher animals. As well as inactivating polyamine uptake, antizyme is induced by polyamine-enhanced translational frameshifting, and binds to ODC, accelerating its ATP-dependent degradation, a process catalysed by the 26S proteasome.
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