Abstract Bone Morphogenetic Protein (BMP) refers to an activity derived from bone that
induces the formation of cartilage and bone in vivo. This activity leads to a series of
developmental processes including chemotaxis, proliferation, and differentiation, which
result in the transient formation of cartilage and the production of living bone tissue,
complete with hematopoietic marrow. The determination of the factor or factors responsible
for this activity has clear significance both for our understanding of bone biology and for the …