[HTML][HTML] A new model for ductal carcinoma in situ suggests strategies for treatment
WJ Gullick - Breast Cancer Research, 2002 - Springer
WJ Gullick
Breast Cancer Research, 2002•SpringerHuman ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due
largely to the introduction of mammographic screening. It has been shown in a cell culture
system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a
DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this
suggests that it could be a target for treatment in this disease.
largely to the introduction of mammographic screening. It has been shown in a cell culture
system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a
DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this
suggests that it could be a target for treatment in this disease.
Abstract
Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor receptor, results in a DCIS-like phenotype. Since overexpression of c-erbB-2 occurs in 60% of DCIS, this suggests that it could be a target for treatment in this disease.
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