[HTML][HTML] Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types
GE Stoica, A Kuo, C Powers, ET Bowden… - Journal of Biological …, 2002 - ASBMB
Midkine (MK) is a developmentally regulated, secreted growth factor homologous to
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK
in human SW-13 cells and studied receptor binding, signal transduction, and activity of MK.
The MK protein stimulates soft agar colony formationin vitro and tumor growth of SW-13 cells
in athymic nude mice, as well as proliferation of human endothelial cells from brain
microvasculature and umbilical vein (HUVEC) in the low ng/ml range. MK binds to …
pleiotrophin (PTN). To investigate the potential role of MK in tumor growth, we expressed MK
in human SW-13 cells and studied receptor binding, signal transduction, and activity of MK.
The MK protein stimulates soft agar colony formationin vitro and tumor growth of SW-13 cells
in athymic nude mice, as well as proliferation of human endothelial cells from brain
microvasculature and umbilical vein (HUVEC) in the low ng/ml range. MK binds to …