LANGERHANS cells (LC) are the principal accessory cells present in epidermis¹. Because LC have limited capacity for self-renewal², epidermis is continually repopulated by as-yet uncharacterized bone marrow-derived LC progenitors^3,4. In addition, although LC persist in epidermis for extended periods, LC are induced to migrate from skin to regional lymph nodes after antigen exposure⁵. To begin to elucidate mechanisms involved in LC trafficking, we characterized LC-keratinocyte (KC) interactions. Here we report that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin. Cultured LC (which may bear a phenotypic and functional relationship to LC that have migrated to lymph nodes^6,7) express lower levels of E-cadherin and exhibit