Prospects for anti-ras drugs.
MR Ahmadian - British journal of haematology, 2002 - search.ebscohost.com
British journal of haematology, 2002•search.ebscohost.com
Review Page 1 Review PROSPECTS FOR ANTI-RAS DRUGS A variety of cellular processes
such as cellular proliferation, differentiation and apoptosis are controlled by the function of Ras
proteins as molecular switches cycling between inactive GDP-bound ÔOFFÕ and active
GTP-bound ÔONÕ states (Lowy & Willumsen, 1993; Reuther & Der, 2000). The states of
nucleotide occupancy are regulated by a variety of proteins including guanine nucleotide
exchange factors (GEFs) and GTPase activating proteins (GAPs) (Bourne et al, 1990, 1991; …
such as cellular proliferation, differentiation and apoptosis are controlled by the function of Ras
proteins as molecular switches cycling between inactive GDP-bound ÔOFFÕ and active
GTP-bound ÔONÕ states (Lowy & Willumsen, 1993; Reuther & Der, 2000). The states of
nucleotide occupancy are regulated by a variety of proteins including guanine nucleotide
exchange factors (GEFs) and GTPase activating proteins (GAPs) (Bourne et al, 1990, 1991; …
Abstract
Focuses on the approaches for the selective blockade of Ras proteins. Background on the functions of Ras proteins; Application of RNA interference; Need to target the membrane association of Ras; Inhibition of Ras activation.
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