Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus
DCE de Goeij, D Jezova, FJH Tilders - Brain research, 1992 - Elsevier
DCE de Goeij, D Jezova, FJH Tilders
Brain research, 1992•ElsevierThe effect of repeated stress on corticotropin-releasing factor (CRF) and vasopressin (AVP)
synthesis in parvocellular neurons of the paraventricular nucleus (PVN) was studied by
means of double label immunocytochemistry. Once daily immobilization of male rats for 16
days leads to a 75% increase in the number of CRF immunoreactive neurons, but a 5-fold
elevation in the number of AVP containing CRF cell bodies. These results demonstrate that
repeated stress activates AVP synthesis in CRF neurons.
synthesis in parvocellular neurons of the paraventricular nucleus (PVN) was studied by
means of double label immunocytochemistry. Once daily immobilization of male rats for 16
days leads to a 75% increase in the number of CRF immunoreactive neurons, but a 5-fold
elevation in the number of AVP containing CRF cell bodies. These results demonstrate that
repeated stress activates AVP synthesis in CRF neurons.
Abstract
The effect of repeated stress on corticotropin-releasing factor (CRF) and vasopressin (AVP) synthesis in parvocellular neurons of the paraventricular nucleus (PVN) was studied by means of double label immunocytochemistry. Once daily immobilization of male rats for 16 days leads to a 75% increase in the number of CRF immunoreactive neurons, but a 5-fold elevation in the number of AVP containing CRF cell bodies. These results demonstrate that repeated stress activates AVP synthesis in CRF neurons.
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