Decreases in mitochondrial respiratory chain complex activities have been implicated in
neurodegenerative disorders such as Parkinson's disease, Huntington's disease, and
Alzheimer's disease. However, the extent to which these decreases cause a disturbance in
oxidative phosphorylation and energy homeostasis in the brain is not known. We therefore
examined the relative contribution of individual mitochondrial respiratory chain complexes to
the control of NAD-linked substrate oxidative phosphorylation in synaptic mitochondria …