Deregulation of the retinoblastoma protein (pRB) pathway is a hallmark of human cancer.
The core members of this pathway include the tumor suppressor protein, pRB, which
through binding to a number of cellular proteins, most notably members of the E2F
transcription factor family, regulates progression through the cell division cycle. With the aim
of identifying transcriptional changes provoked by deregulation of the pRB pathway, we
have used cell lines that conditionally express a constitutively active phosphorylation site …