The cell cycle inhibitor p16INK4A sensitizes lymphoblastic leukemia cells to apoptosis by physiologic glucocorticoid levels
MJ Ausserlechner, P Obexer, GJ Wiegers… - Journal of Biological …, 2001 - ASBMB
The cyclin-dependent kinase inhibitor p16 INK4A is frequently inactivated in childhood T-cell
acute lymphoblastic leukemia. To investigate possible consequences of this genetic
alteration for tumor development, we conditionally expressed p16 INK4A in the T-cell acute
lymphoblastic leukemia line CCRF-CEM, which carries a homozygous deletion of this gene.
In agreement with its reported function, p16 INK4A expression was associated with
hypophosphorylation of the retinoblastoma protein pRB and stable cell cycle arrest in G 0/G …
acute lymphoblastic leukemia. To investigate possible consequences of this genetic
alteration for tumor development, we conditionally expressed p16 INK4A in the T-cell acute
lymphoblastic leukemia line CCRF-CEM, which carries a homozygous deletion of this gene.
In agreement with its reported function, p16 INK4A expression was associated with
hypophosphorylation of the retinoblastoma protein pRB and stable cell cycle arrest in G 0/G …
