Inhibition of CD40 signaling pathway in antigen presenting cells by T suppressor cells
Z Liu, S Tugulea, R Cortesini, S Lederman… - Human immunology, 1999 - Elsevier
Understanding the mechanism which underlies the induction of immunologic tolerance is
crucial to the development of strategies for treatment of autoimmune diseases and allograft
rejection. Although the concept that T suppressor cells (Ts) downregulate the immune
response has long been accepted, the existence of a distinct population of lymphocytes that
mediates suppression has not been convincingly demonstrated. In previous studies, we
have utilized human T cell lines (TCLs) to analyze the suppressive effects of CD8+ CD28− T …
crucial to the development of strategies for treatment of autoimmune diseases and allograft
rejection. Although the concept that T suppressor cells (Ts) downregulate the immune
response has long been accepted, the existence of a distinct population of lymphocytes that
mediates suppression has not been convincingly demonstrated. In previous studies, we
have utilized human T cell lines (TCLs) to analyze the suppressive effects of CD8+ CD28− T …
