Regional variation of the αβ T cell repertoire in the colon of healthy individuals and patients with Crohn's disease
E May, C Lambert, W Holtmeier, A Hennemann… - Human immunology, 2002 - Elsevier
Clonally expanded T cells might be involved in the pathogenesis of Crohn's disease (CD).
To test the impact of CD on the regional distribution of expanded T cells, this study analyzed
the T cell receptor β (TCRB) repertoire within colonic biopsy specimens from 12 CD patients
and 6 noninflammatory controls by TCR spectratyping. Migration characteristics of dominant
CDR3 bands from different sites of the normal mucosa suggested focal, segmental, or
ubiquitous spreading of individual expanded clones. Similar patterns were observed when …
To test the impact of CD on the regional distribution of expanded T cells, this study analyzed
the T cell receptor β (TCRB) repertoire within colonic biopsy specimens from 12 CD patients
and 6 noninflammatory controls by TCR spectratyping. Migration characteristics of dominant
CDR3 bands from different sites of the normal mucosa suggested focal, segmental, or
ubiquitous spreading of individual expanded clones. Similar patterns were observed when …