Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness, symptoms, and medication
V Kumari, W Soni, VM Mathew… - Archives of general …, 2000 - jamanetwork.com
Background Prepulse inhibition of the startle reflex response refers to the ability of a weak
prestimulus to transiently inhibit the response to a closely following strong sensory stimulus.
This effect represents an operational index of sensorimotor gating and is found to be
deficient in schizophrenia. Prepulse inhibition deficits in schizophrenia seem to be partially
normalized by typical antipsychotics and more fully by some atypical antipsychotics. Early
onset of schizophrenia, particularly in men, has been associated with abnormal brain …
prestimulus to transiently inhibit the response to a closely following strong sensory stimulus.
This effect represents an operational index of sensorimotor gating and is found to be
deficient in schizophrenia. Prepulse inhibition deficits in schizophrenia seem to be partially
normalized by typical antipsychotics and more fully by some atypical antipsychotics. Early
onset of schizophrenia, particularly in men, has been associated with abnormal brain …
