[HTML][HTML] β-Adrenergic pathway induces apoptosis through calcineurin activation in cardiac myocytes
S Saito, Y Hiroi, Y Zou, R Aikawa, H Toko… - Journal of Biological …, 2000 - ASBMB
Apoptosis of cardiac myocytes is one of the causes of heart failure. Here we examine the
mechanism by which the activation of β-adrenergic receptor induces cardiomyocyte
apoptosis. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling and
DNA ladder analyses revealed that isoproterenol (Iso) induced the apoptosis of cardiac
myocytes of neonatal rats through an increase in intracellular Ca 2+ levels. The Iso-induced
cardiomyocyte apoptosis was strongly inhibited by the L-type Ca 2+ channel antagonist …
mechanism by which the activation of β-adrenergic receptor induces cardiomyocyte
apoptosis. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling and
DNA ladder analyses revealed that isoproterenol (Iso) induced the apoptosis of cardiac
myocytes of neonatal rats through an increase in intracellular Ca 2+ levels. The Iso-induced
cardiomyocyte apoptosis was strongly inhibited by the L-type Ca 2+ channel antagonist …
