Role of caspases in hypoxia-induced necrosis of rat renal proximal tubules
CL Edelstein, Y Shi, RW Schrier - Journal of the American Society …, 1999 - journals.lww.com
The role of the caspases, a newly discovered group of cysteine proteases, was investigated
in a model of hypoxia-induced necrotic injury of rat renal proximal tubules. An assay for
caspases in freshly isolated rat proximal tubules was developed. There was a 40% increase
in tubular caspase activity after 15 min of hypoxia in association with increased cell
membrane damage as indicated by a threefold increase in lactate dehydrogenase release.
The specific caspase inhibitor Z-Asp-2, 6-dichlorobenzoyloxymethylketone (ZD-DCB) …
in a model of hypoxia-induced necrotic injury of rat renal proximal tubules. An assay for
caspases in freshly isolated rat proximal tubules was developed. There was a 40% increase
in tubular caspase activity after 15 min of hypoxia in association with increased cell
membrane damage as indicated by a threefold increase in lactate dehydrogenase release.
The specific caspase inhibitor Z-Asp-2, 6-dichlorobenzoyloxymethylketone (ZD-DCB) …