Synthetic peptides that inhibit binding of the myelin basic protein 85-99 epitope to multiple sclerosis-associated HLA-DR2 molecules and MBP-specific T-cell …
M Fridkis-Hareli, JNH Stern, L Fugger, JL Strominger - Human immunology, 2001 - Elsevier
Copolymer 1 (Cop 1, poly [Y, E, A, K]) is a random synthetic amino acid copolymer effective
in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-
DR2 (DRB1∗ 1501). In the present study various peptides, synthesized according to the
binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a
candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to
disease-associated HLA-DR2 (DRB1∗ 1501) molecules. In particular, two peptides with …
in the treatment of relapsing forms of multiple sclerosis (MS), a disease that is linked to HLA-
DR2 (DRB1∗ 1501). In the present study various peptides, synthesized according to the
binding motifs for both the immunodominant epitope of myelin basic protein (MBP) 85-99, a
candidate autoantigen in MS, and Cop 1, differentially inhibited binding of these antigens to
disease-associated HLA-DR2 (DRB1∗ 1501) molecules. In particular, two peptides with …