[HTML][HTML] Analysis of cytokine signaling in patients with extrinsic asthma and hyperimmunoglobulin E
RL Miller, TM Eppinger, D McConnell… - Journal of allergy and …, 1998 - Elsevier
Background: Recent data suggest that the regulation of class switching to IgE by cytokines is
mediated by STAT transcription factors. The induction of IgE by IL-4 and IL-13 occurs
through the activation of the intracellular signal-transducing protein Stat6, whereas the
inhibition of IgE class switching by interferon-γ (IFN-γ) occurs through the activation of Stat1.
Objective: We hypothesized that in extrinsic asthma or in cases of markedly elevated IgE (ie,
hyperimmunoglobulin E [HIE]) increased levels of IgE may be associated with alterations in …
mediated by STAT transcription factors. The induction of IgE by IL-4 and IL-13 occurs
through the activation of the intracellular signal-transducing protein Stat6, whereas the
inhibition of IgE class switching by interferon-γ (IFN-γ) occurs through the activation of Stat1.
Objective: We hypothesized that in extrinsic asthma or in cases of markedly elevated IgE (ie,
hyperimmunoglobulin E [HIE]) increased levels of IgE may be associated with alterations in …
