Differential regulation of discrete apoptotic pathways by Ras
CY Chen, J Liou, LW Forman, DV Faller - Journal of Biological Chemistry, 1998 - ASBMB
The products of the ras genes are known to regulate cell proliferation and differentiation;
recently, they have been found to play a role in apoptosis. The expression of oncogenic p21
ras in a number of cell types, including Jurkat (a human T lymphoblastoid cell line) and
murine fibroblasts, makes the cells susceptible to apoptosis following suppression of protein
kinase C (PKC) activity (PKC/Ras-mediated apoptosis). Engagement of Fas antigen, a
potent effector of apoptosis, activates cellular p21 ras, which may be required for completion …
recently, they have been found to play a role in apoptosis. The expression of oncogenic p21
ras in a number of cell types, including Jurkat (a human T lymphoblastoid cell line) and
murine fibroblasts, makes the cells susceptible to apoptosis following suppression of protein
kinase C (PKC) activity (PKC/Ras-mediated apoptosis). Engagement of Fas antigen, a
potent effector of apoptosis, activates cellular p21 ras, which may be required for completion …
