[HTML][HTML] Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-κB DNA binding activity
BM Matata, M Galiñanes - Journal of Biological Chemistry, 2002 - ASBMB
The mechanism of release of proinflammatory cytokines by peripheral blood monocytes is
unknown. Peroxynitrite (ONOO−) formed by the reaction of nitric oxide (NO) and superoxide
is released predominantly by inflammatory cells at the site of injury in several inflammatory
pathologies. Here we show that human monocytes treated with ONOO− at micromolar
concentrations induce a dose-dependent release of proinflammatory cytokines. These
effects were not antagonized by up to 100 μmepigallocatechin gallate, an inhibitor of protein …
unknown. Peroxynitrite (ONOO−) formed by the reaction of nitric oxide (NO) and superoxide
is released predominantly by inflammatory cells at the site of injury in several inflammatory
pathologies. Here we show that human monocytes treated with ONOO− at micromolar
concentrations induce a dose-dependent release of proinflammatory cytokines. These
effects were not antagonized by up to 100 μmepigallocatechin gallate, an inhibitor of protein …
